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(Science History Images via Alamy)

The Humans Who Live as Lab Rats

Meet the men and women who get paid to be injected with brand-new wonder drugs.

The trainee couldn’t find Raighne Hogan’s vein. They were at an inpatient facility in West Bend, Wisconsin, northwest of Milwaukee, and she was maybe 18, and she was trying to draw his blood. She kept poking and prodding his forearm. No dice. When Hogan started to bleed all over himself, down his arm, his wrist, she fainted. He remembers sitting there. No nurses in sight.

It wasn’t the first time something like this had happened. 

“It’s like in any hospital,” Hogan told me. Sometimes they know what they’re doing; sometimes you walk out in worse shape than when you walked in.

Hogan likes to think of himself as a professional. He’s done—what?—maybe 20 clinical trials. Seems like more. He prefers longer studies, the ones that stretch on for at least a month. (Longer trials can run up to six months.)

Phlebotomists who don’t know how to draw blood are just part of the deal.

Just like taking part in a Phase I, “first-in-human” study is part of the deal. As in, this is the first time a brand-new wonder drug that may (or may not) kill you is being injected into a person.

Hogan remembered one in particular. They ran an EKG later, and when it came back Hogan said it looked like his heart was “too big for his body.” 

After that, he said, “I didn’t know what my life span was going to be.” 

It turned out Hogan was fine. His heart seemed okay. And so he kept enrolling in trials. 

Hogan is a lab rat—a professional participant in clinical drug trials. And his job—it had started out as a curiosity that turned into a side hustle that became a full-time, freelance gig—is to travel the country, sometimes the world, at the behest of Big Pharma. 

There are three phases in every drug trial. Phase I is the safety trial. Phase II is for effectiveness and dosage. Phase III is all about package labeling, drug interactions—the fine print on the inside flap of the bottle after the Food and Drug Administration signs off. The lab rats are mostly on the Phase I circuit. Sometimes Phase II. 

They didn’t used to be a thing—lab rats. Now, they are a growing subset of that amorphous and sprawling beast known as the gig economy, and depending on who you ask, they are lazy, or they have a penchant for risk-taking, or they are martyrs for modern medicine. They are the people who ensure the drugs we swallow, inject, spray, rub, or otherwise ingest won’t kill us. 

Until the early 1970s, almost all Phase I trials involved inmates, Roberto Abadie, a sociologist at the University of Nebraska–Lincoln and the author of The Professional Guinea Pig: Big Pharma and the Risky World of Human Subjects, told me. That stopped after concerns arose about prisoners being coerced into taking part. 

So, the pharmaceutical companies started buying newspaper ads looking for paid volunteers, offering quick, easy money that was usually paid out in one lump sum. A typical study paid anywhere from a few hundred bucks to a thousand dollars.

In the 1980s, Abadie said, “career volunteers” started to pop up. At the time, it was more of an underground thing. The volunteers were more bohemian. They published homemade zines—DIY magazines filled with tips like which trials were safe and which clinics paid best.

By the mid-2000s, the zines had turned into web forums like Just Another Lab Rat!, run by Paul Clough. Today, Clough is arguably the best-known lab rat in the country. His blood has been drawn thousands of times. He’s a veteran. He’s famous.

By the 2010s, there were group chats on WhatsApp, where people shared information about gigs that paid into the tens of thousands. There were more forums and websites. There were YouTubers. They had a presence on Instagram and then TikTok, and a small Facebook footprint. 

Gradually, the lab rats morphed into cogs coursing through an efficient and organized network of blood-draw centers and testing facilities. As the need for more cogs grew—there were, by now, thousands of lab rats, but the demand for new bodies was never-ending—recruiting companies sprouted. Eventually, the recruiting companies started to administer the clinical trial tests—the better to speed up the process for the pharmaceutical giants, which were always on the hunt for the next multibillion-dollar cancer treatment, cholesterol buster, or anti-dementia drug.

(Science History Images via Alamy)

Today, the lab-rat economy is efficient, streamlined, corporate. The way one joins or is recruited has a certain rhythm.

First, there’s the ad. Usually, it’s an emoji-laden message in all caps that you might come across on social media, on a hospital or university bulletin board, on Craigslist, in a forum, or in an invite-only group chat: you—your organism—in exchange for $8,000, $10,000, even $30,000. The ads are usually posted by recruiting companies or fellow lab rats looking for recruiting fees.

Second, there’s the prescreening call: confirmation that you, the prospective lab rat, know what you’re getting into.

Third, there’s the physical. This takes place at some faceless facility, often in a faceless strip mall. The facilities, as described by lab rats, are usually quiet, sterile, bleach-soaked—a halfway point between a mental institution and a generic office. White walls, fluorescent lighting, linoleum. 

Julie Moskal, a cheery, 56-year-old school bus driver with a shock of fire engine–red hair, was a professional lab rat while saving money to care for her dad, who was ill. She was especially fond of Labcorp, a facility in Madison, Wisconsin, which she described as “better than a hospital, and a little worse than a hotel.”

If you pass the physical, you start the trial immediately. (Lab rats show up for the exam with a suitcase.) This is where you live for the duration of the study. You are now, as the lab rats put it, in “drug jail.”

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