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The Drug Turning Philadelphia into a Zombieland
A man named Sean stops on Kensington Avenue in Philadelphia, where medetomidine is being added to fentanyl. (Courtesy of The Dispatch, Photography by Vincent Guglielmo)
First heroin, then fentanyl, then tranq. Now medetomidine is hollowing out Kensington Avenue in Philadelphia, the country’s most notorious open-air drug market.
By Mattha Busby
12.09.25 — Health and Self-Improvement
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This piece was originally published in Dispatch.

Folks come here for the drugs. Sons, daughters, mothers, and fathers, all drawn by the promise of the strongest and cheapest highs in America. Somehow, they—the drugs and the people—always end up on Kensington Avenue in Philadelphia, the country’s most notorious open-air drug market.

For years the street ran on heroin; then gangs started putting fentanyl, or “fetty,” in the dope. Then came the animal tranquilizer xylazine, known locally simply as “tranq.” Now, there is something new: medetomidine.

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Mattha Busby
Mattha Busby is a journalist with a focus on health policy, drugs, and culture. He is the author of Psychedelics.
Tags:
Health
Mental Health
Drugs
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